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Overweight person has less motivation to control appetite

Diet desperately often fail when you see good food presented on the dinner table. This is commonplace. Not because of intentions, but this phenomenon actually happens because the brain fat people respond to different foods with skinny people.

In obese people, even when the brain knows the body is not hungry, the brain responds to food as if the body is in need of food. That means that when obese people try to lose weight, they may have to fight with an unconscious nerve center that encourages it to eat.

In people of normal weight, the nervous system that strengthens positive feelings associated with food will die when blood sugar levels return to normal after meals. This signal indicates that the body's need for calories has been met. But in obese people, the center of the nerves in the midbrain remains active when looking at high-calorie foods, even when their blood sugar levels are normal.

"The role of glucose regulation is lost in people with obesity, which may explain the strong impulse to eat in some obese people, no matter how much they have eaten," said Elissa Epel of the University of California, San Francisco, an obesity researcher not involved in this research.

In this study, nine lean and five adult volunteers with obesity were shown photographs of foods such as ice cream, fries, cabbage, or salads while undergoing brain scans. Throughout the procedure, researchers asked the study participants to assess their hunger and how much they wanted the food.

The study participants underwent brain scans several hours after eating. The researchers used insulin pumps to stabilize blood sugar levels of study participants at normal levels (about 90 milligrams per deciliter) or close to low (about 70 milligrams per deciliter).

"Low blood sugar levels can occur briefly during the day, especially in diabetics or metabolic disorders that cause diabetes," said endocrinologist Robert Sherwin of Yale University, one of the study authors.

All study participants reported wanting to eat when their blood glucose was low, especially high-calorie foods. Brain scans show that the prefrontal cortex or part of the brain that controls reason and willpower become inactive when blood glucose is low, while the area of ​​the brain that drives feeding remains active. In skinny people, this tendency is opposite when blood glucose is normal.

"The part of the brain that allows people to consciously exert their willpower is largely inactive in obese people, suggesting that brain differences in obese people can perpetuate obesity," Sherwin said as quoted by on Tuesday (11/11/2011). ).

Although small, the study was well designed and controlled. "It allows us to see accurate results in relatively small differences," said obesity scientist Dianne Lattemann of the Veterans Affairs Puget Sound Health Care System in Seattle.

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